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STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels
Stromal interacting molecule 1 (STIM1) is a Ca(2+) sensor that conveys the Ca(2+) load of the endoplasmic reticulum to store-operated channels (SOCs) at the plasma membrane. Here, we report that STIM1 binds TRPC1, TRPC4 and TRPC5 and determines their function as SOCs. Inhibition of STIM1 function in...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699187/ https://ncbi.nlm.nih.gov/pubmed/17486119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1590 |
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