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STIM1 gates TRPC channels but not Orai1 by electrostatic interaction

The receptor-evoked Ca(2+) signal includes activation of the store-operated channels (SOCs) TRPC and Orai channels. Although both are gated by STIM1, it is not known how STIM1 gates the channels and whether STIM1 gates the TRPCs and Orais by the same mechanism. Here, we report the molecular mechanis...

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Dettagli Bibliografici
Autori principali: Zeng, Weizhong, Yuan, Joseph P., Kim, Min Seuk, Choi, Young Jin, Huang, Guo N., Worley, Paul F., Muallem, Shmuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586614/
https://ncbi.nlm.nih.gov/pubmed/18995841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.09.020
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