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Native Store-operated Ca(2+) Influx Requires the Channel Function of Orai1 and TRPC1

With the discovery of STIM1 and Orai1 and gating of both TRPC and Orai1 channels by STIM1, a central question is the role of each of the channels in the native store-operated Ca(2+) influx (SOCs). Here, we used a strategy of knockdown of Orai1 and of TRPC1 alone and in combination and rescue by smal...

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Detalhes bibliográficos
Main Authors: Kim, Min Seuk, Zeng, Weizhong, Yuan, Joseph P., Shin, Dong Min, Worley, Paul F., Muallem, Shmuel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665094/
https://ncbi.nlm.nih.gov/pubmed/19228695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808097200
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