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Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors

Binding-induced biomolecular switches are used throughout nature and, increasingly, throughout biotechnology for the detection of chemical moieties and the subsequent transduction of this detection into useful outputs. Here we show that the thermodynamics of these switches are quantitatively describ...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Vallée-Bélisle, Alexis, Ricci, Francesco, Plaxco, Kevin W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728975/
https://ncbi.nlm.nih.gov/pubmed/19666496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904005106
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