Discovery of a novel class of AKT pleckstrin homology (PH) domain inhibitors

AKT, a phospholipid binding-serine/threonine kinase, is a key component of the phosphoinositide 3-kinase (PI3K) cell survival signaling pathway that is aberrantly activated in many human cancers. Many attempts have been made to inhibit AKT; however, selectivity remains to be achieved. We have develo...

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Bibliografische gegevens
Hoofdauteurs: Mahadevan, Daruka, Powis, Garth, Mash, Eugene A., George, Benjamin, Gokhale, Vijay M., Zhang, Shuxing, Shakalya, Kishore, Du-Cuny, Lei, Berggren, Margareta, Ali, M. Ahad, Jana, Umasish, Ihle, Nathan, Moses, Sylvestor, Franklin, Chloe, Narayan, Satya, Shirahatti, Nikhil, Meuillet, Emmanuelle J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727864/
https://ncbi.nlm.nih.gov/pubmed/18790745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-2276
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