REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase

The cellular response to hypoxia involves several signalling pathways that mediate adaptation and survival. REDD1 (regulated in development and DNA damage responses 1), a hypoxia-inducible factor-1 target gene, has a crucial role in inhibiting mammalian target of rapamycin complex 1 (mTORC1) signall...

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Detalhes bibliográficos
Main Authors: Katiyar, Samiksha, Liu, Enbo, Knutzen, Christine A, Lang, Elizabeth S, Lombardo, Christian R, Sankar, Sabita, Toth, Julia I, Petroski, Matthew D, Ronai, Ze'ev, Chiang, Gary G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726664/
https://ncbi.nlm.nih.gov/pubmed/19557001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.93
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