Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain

α-Synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is sufficient to cause early-onset, familial PD. A critical qu...

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Autori principali: Cronin, Kenneth D., Ge, Dongliang, Manninger, Paul, Linnertz, Colton, Rossoshek, Anna, Orrison, Bonnie M., Bernard, David J., El-Agnaf, Omar M.A., Schlossmacher, Michael G., Nussbaum, Robert L., Chiba-Falek, Ornit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2009
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722989/
https://ncbi.nlm.nih.gov/pubmed/19498036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp265
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