Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain

α-Synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is sufficient to cause early-onset, familial PD. A critical qu...

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Detaylı Bibliyografya
Asıl Yazarlar: Cronin, Kenneth D., Ge, Dongliang, Manninger, Paul, Linnertz, Colton, Rossoshek, Anna, Orrison, Bonnie M., Bernard, David J., El-Agnaf, Omar M.A., Schlossmacher, Michael G., Nussbaum, Robert L., Chiba-Falek, Ornit
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2009
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722989/
https://ncbi.nlm.nih.gov/pubmed/19498036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp265
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