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MurF Inhibitors with Antibacterial Activity: Effect on Muropeptide Levels

MurF catalyzes the last cytoplasmic step of bacterial cell wall synthesis and is essential for bacterial survival. Our previous studies used a pharmacophore model of a MurF inhibitor to identify additional inhibitors with improved properties. We now present the characterization of two such inhibitor...

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Autors principals: Baum, Ellen Z., Crespo-Carbone, Steven M., Foleno, Barbara D., Simon, Lee D., Guillemont, Jerome, Macielag, Mark, Bush, Karen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715636/
https://ncbi.nlm.nih.gov/pubmed/19470511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00166-09
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