A MurF Inhibitor That Disrupts Cell Wall Biosynthesis in Escherichia coli

MurF is an essential enzyme of bacterial cell wall biosynthesis. Few MurF inhibitors have been reported, and none have displayed measurable antibacterial activity. Through the use of a MurF binding assay, a series of 8-hydroxyquinolines that bound to the Escherichia coli enzyme and inhibited its act...

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Hauptverfasser: Baum, Ellen Z., Crespo-Carbone, Steven M., Klinger, Alexandra, Foleno, Barbara D., Turchi, Ignatius, Macielag, Mark, Bush, Karen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2007
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2167990/
https://ncbi.nlm.nih.gov/pubmed/17908943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00845-07
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