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Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF

BACKGROUND: To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa. MurF catalyzes the formation of a peptide bond between D-Alanyl-D-Alanine (D-Ala-D-Ala...

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Detalhes bibliográficos
Main Authors: Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, François, Clarke, Tom, Blewett, Ann, Bugg, Timothy DH, Levesque, Roger C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626591/
https://ncbi.nlm.nih.gov/pubmed/19099588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-9-33
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