Utility of Muropeptide Ligase for Identification of Inhibitors of the Cell Wall Biosynthesis Enzyme MurF

MurF is a key enzyme in the biosynthesis of the bacterial cell wall in both gram-positive and gram-negative bacteria. This enzyme has not been extensively exploited as a drug target, possibly due to the difficulty in obtaining one of the substrates, UDP-MurNAc-l-Ala-γ-d-Glu-meso-diaminopimelate, whi...

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Detalhes bibliográficos
Main Authors: Baum, Ellen Z., Crespo-Carbone, Steven M., Abbanat, Darren, Foleno, Barbara, Maden, Amy, Goldschmidt, Raul, Bush, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346814/
https://ncbi.nlm.nih.gov/pubmed/16377691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.230-236.2006
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