Identification and Characterization of New Inhibitors of the Escherichia coli MurA Enzyme

The bacterial enzyme MurA catalyzes the transfer of enolpyruvate from phosphoenolpyruvate (PEP) to uridine diphospho-N-acetylglucosamine (UNAG), which is the first committed step of bacterial cell wall biosynthesis. From high-throughput screening of a chemical library, three novel inhibitors of the...

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Autores principales: Baum, Ellen Z., Montenegro, Deborah A., Licata, Lisa, Turchi, Ignatius, Webb, Glenda C., Foleno, Barbara D., Bush, Karen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC90801/
https://ncbi.nlm.nih.gov/pubmed/11600375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.11.3182-3188.2001
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