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Identification and Characterization of New Inhibitors of the Escherichia coli MurA Enzyme
The bacterial enzyme MurA catalyzes the transfer of enolpyruvate from phosphoenolpyruvate (PEP) to uridine diphospho-N-acetylglucosamine (UNAG), which is the first committed step of bacterial cell wall biosynthesis. From high-throughput screening of a chemical library, three novel inhibitors of the...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2001
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC90801/ https://ncbi.nlm.nih.gov/pubmed/11600375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.11.3182-3188.2001 |
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