Identification and Characterization of New Inhibitors of the Escherichia coli MurA Enzyme

The bacterial enzyme MurA catalyzes the transfer of enolpyruvate from phosphoenolpyruvate (PEP) to uridine diphospho-N-acetylglucosamine (UNAG), which is the first committed step of bacterial cell wall biosynthesis. From high-throughput screening of a chemical library, three novel inhibitors of the...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Baum, Ellen Z., Montenegro, Deborah A., Licata, Lisa, Turchi, Ignatius, Webb, Glenda C., Foleno, Barbara D., Bush, Karen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90801/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11600375/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.11.3182-3188.2001
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