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Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset
The age of onset of Huntington's disease (HD) is determined primarily by the length of the HD CAG repeat mutation, but is also influenced by other modifying factors. Delineating these modifiers is a critical step towards developing validated therapeutic targets in HD patients. The HD CAG repeat...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714728/ https://ncbi.nlm.nih.gov/pubmed/19465745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp242 |
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