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Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset

The age of onset of Huntington's disease (HD) is determined primarily by the length of the HD CAG repeat mutation, but is also influenced by other modifying factors. Delineating these modifiers is a critical step towards developing validated therapeutic targets in HD patients. The HD CAG repeat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Swami, Meera, Hendricks, Audrey E., Gillis, Tammy, Massood, Tiffany, Mysore, Jayalakshmi, Myers, Richard H., Wheeler, Vanessa C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714728/
https://ncbi.nlm.nih.gov/pubmed/19465745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp242
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