A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism

OCRL, whose mutations are responsible for Lowe syndrome and Dent disease, and INPP5B are two similar proteins comprising a central inositol 5-phosphatase domain followed by an ASH and a RhoGAP-like domain. Their divergent NH2-terminal portions remain uncharacterized. We show that the NH2-terminal re...

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Detalhes bibliográficos
Main Authors: Mao, Yuxin, Balkin, Daniel M, Zoncu, Roberto, Erdmann, Kai S, Tomasini, Livia, Hu, Fenghua, Jin, Moonsoo M, Hodsdon, Michael E, De Camilli, Pietro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711190/
https://ncbi.nlm.nih.gov/pubmed/19536138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.155
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