A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

Mutations in the inositol 5-phosphatase OCRL cause Lowe syndrome and Dent's disease. Although OCRL, a direct clathrin interactor, is recruited to late-stage clathrin-coated pits, clinical manifestations have been primarily attributed to intracellular sorting defects. Here we show that OCRL loss...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Nández, Ramiro, Balkin, Daniel M, Messa, Mirko, Liang, Liang, Paradise, Summer, Czapla, Heather, Hein, Marco Y, Duncan, James S, Mann, Matthias, De Camilli, Pietro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2014
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358339/
https://ncbi.nlm.nih.gov/pubmed/25107275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02975
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