Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling

Sealing of phagosomes is accompanied by the disappearance of phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P(2)) from their cytoplasmic leaflet. Elimination of PtdIns(4,5)P(2), which is required for actin remodeling during phagosome formation, has been attributed to hydrolysis by phospholipase...

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Bibliographic Details
Main Authors: Bohdanowicz, Michal, Balkin, Daniel M., De Camilli, Pietro, Grinstein, Sergio
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248896/
https://ncbi.nlm.nih.gov/pubmed/22072788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-06-0489
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