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Uridine-based inhibitors as new leads for antibiotics targeting E. coli LpxC
The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC catalyzes the committed reaction of lipid A (endotoxin) biosynthesis in Gram-negative bacteria and is a validated antibiotic target. Although several previously described compounds bind to the unique acyl chain binding passage of Lpx...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2709817/ https://ncbi.nlm.nih.gov/pubmed/19256534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900167q |
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