Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

Seven-transmembrane-spanning receptors (7TMRs) are prominent drug targets. However, small-molecule ligands for 7-transmembrane-spanning receptors for which the natural ligands are large, heterodimeric glycoprotein hormones, like thyroid-stimulating hormone (TSH; thyrotropin), have only recently been...

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Main Authors: Neumann, Susanne, Huang, Wenwei, Titus, Steve, Krause, Gerd, Kleinau, Gunnar, Alberobello, Anna Teresa, Zheng, Wei, Southall, Noel T., Inglese, James, Austin, Christopher P., Celi, Francesco S., Gavrilova, Oksana, Thomas, Craig J., Raaka, Bruce M., Gershengorn, Marvin C.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2009
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708975/
https://ncbi.nlm.nih.gov/pubmed/19592511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904506106
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