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Interrogating the Molecular Basis for Multiple Macrolactone Ring Formation by the Pikromycin Polyketide Synthase

The pikromycin polyketide synthase (PKS) is unique in its ability to generate both 12-and 14-membered ring macrolactones. As such, dissection of the molecular basis for controlling metabolic diversity in this system remains an important objective for understanding modular PKS function and expanding...

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Bibliografiske detaljer
Main Authors: Kittendorf, Jeffrey D., Beck, Brian J., Buchholz, Tonia J., Seufert, Wolfgang, Sherman, David H.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707933/
https://ncbi.nlm.nih.gov/pubmed/17719493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.07.013
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