Synthesis and Biochemical Analysis of Complex Chain-Elongation Intermediates for Interrogation of Molecular Specificity in the Erythromycin and Pikromycin Polyketide Synthases

The 6-deoxyerythronolide B synthase (DEBS) and pikromycin (Pik) modular polyketide synthases are unique multifunctional enzyme systems that are responsible for the biosynthesis of the erythromycin and pikromycin 14-membered ring aglycones, respectively. Together, these natural product biosynthetic s...

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Bibliographic Details
Main Authors: Mortison, Jonathan D., Kittendorf, Jeffrey D., Sherman, David H.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796446/
https://ncbi.nlm.nih.gov/pubmed/19810731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9060596
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