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Synthesis and Biochemical Analysis of Complex Chain-Elongation Intermediates for Interrogation of Molecular Specificity in the Erythromycin and Pikromycin Polyketide Synthases
The 6-deoxyerythronolide B synthase (DEBS) and pikromycin (Pik) modular polyketide synthases are unique multifunctional enzyme systems that are responsible for the biosynthesis of the erythromycin and pikromycin 14-membered ring aglycones, respectively. Together, these natural product biosynthetic s...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796446/ https://ncbi.nlm.nih.gov/pubmed/19810731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9060596 |
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