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Shape shifting leads to small molecule allosteric drug discovery
Enzymes that regulate their activity by modulating an equilibrium of alternate, non-additive, functionally distinct oligomeric assemblies (morpheeins) define a novel mode of allostery (Jaffe, TiBS 30:490-7, 2005). The oligomeric equilibrium for porphobilinogen synthase (PBGS) consists of high-activi...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2703447/ https://ncbi.nlm.nih.gov/pubmed/18559269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.04.012 |
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