Kinetic control of negative feedback regulators of NF-κB/RelA determines their pathogen- and cytokine-receptor signaling specificity

Mammalian signaling networks contain an abundance of negative feedback regulators that may have overlapping (“fail-safe”) or specific functions. Within the NF-κB signaling module, IκBα is known as a negative feedback regulator, but the newly characterized inhibitor IκBδ is also inducibly expressed i...

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Bibliographic Details
Main Authors: Shih, Vincent F.-S., Kearns, Jeffrey D., Basak, Soumen, Savinova, Olga V., Ghosh, Gourisankar, Hoffmann, Alexander
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701028/
https://ncbi.nlm.nih.gov/pubmed/19487661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812367106
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