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Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB

Signaling pathways often share molecular components, tying the activity of one pathway to the functioning of another. In the NFκB signaling system, distinct kinases mediate inflammatory and developmental signaling via RelA and RelB, respectively. Although the substrates of the developmental, so-call...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mitchell, Simon, Hoffmann, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535030/
https://ncbi.nlm.nih.gov/pubmed/31048505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816000116
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