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Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB

Signaling pathways often share molecular components, tying the activity of one pathway to the functioning of another. In the NFκB signaling system, distinct kinases mediate inflammatory and developmental signaling via RelA and RelB, respectively. Although the substrates of the developmental, so-call...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Mitchell, Simon, Hoffmann, Alexander
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535030/
https://ncbi.nlm.nih.gov/pubmed/31048505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816000116
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