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Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB

Signaling pathways often share molecular components, tying the activity of one pathway to the functioning of another. In the NFκB signaling system, distinct kinases mediate inflammatory and developmental signaling via RelA and RelB, respectively. Although the substrates of the developmental, so-call...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Mitchell, Simon, Hoffmann, Alexander
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535030/
https://ncbi.nlm.nih.gov/pubmed/31048505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816000116
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