B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel

Targeted deletion of BAFF causes severe deficiency of splenic B cells. BAFF-R is commonly thought to signal to nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB)–inducing kinase dependent noncanonical NF-κB RelB. However, RelB-deficient mice have normal B-cell numbers. Recent studies...

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Udgivet i:Blood
Main Authors: Almaden, Jonathan V., Liu, Yi C., Yang, Edward, Otero, Dennis C., Birnbaum, Harry, Davis-Turak, Jeremy, Asagiri, Masataka, David, Michael, Goldrath, Ananda W., Hoffmann, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Immunobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786837/
https://ncbi.nlm.nih.gov/pubmed/26773039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-606988
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