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IκBε is a key regulator of B-cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner

The transcription factor NFκB is a regulator of inflammatory and adaptive immune responses, yet only IκBα has been shown to limit NFκB activation and inflammatory responses. We investigated another negative feedback regulator, IκBε, in regulating B cell proliferation and survival. The loss of IκBε s...

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Detalhes bibliográficos
Main Authors: Alves, Bryce N., Tsui, Rachel, Almaden, Jon, Shokhirev, Maxim N., Davis-Turak, Jeremy, Fujimoto, Jessica, Birnbaum, Harry, Ponomarenko, Julia, Hoffmann, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965642/
https://ncbi.nlm.nih.gov/pubmed/24591377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302351
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