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IκBε is a key regulator of B-cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner
The transcription factor NFκB is a regulator of inflammatory and adaptive immune responses, yet only IκBα has been shown to limit NFκB activation and inflammatory responses. We investigated another negative feedback regulator, IκBε, in regulating B cell proliferation and survival. The loss of IκBε s...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3965642/ https://ncbi.nlm.nih.gov/pubmed/24591377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302351 |
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