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IκBɛ provides negative feedback to control NF-κB oscillations, signaling dynamics, and inflammatory gene expression

NF-κB signaling is known to be critically regulated by the NF-κB–inducible inhibitor protein IκBα. The resulting negative feedback has been shown to produce a propensity for oscillations in NF-κB activity. We report integrated experimental and computational studies that demonstrate that another IκB...

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Bibliografiske detaljer
Main Authors: Kearns, Jeffrey D., Basak, Soumen, Werner, Shannon L., Huang, Christine S., Hoffmann, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063883/
https://ncbi.nlm.nih.gov/pubmed/16735576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200510155
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