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IκBɛ provides negative feedback to control NF-κB oscillations, signaling dynamics, and inflammatory gene expression
NF-κB signaling is known to be critically regulated by the NF-κB–inducible inhibitor protein IκBα. The resulting negative feedback has been shown to produce a propensity for oscillations in NF-κB activity. We report integrated experimental and computational studies that demonstrate that another IκB...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063883/ https://ncbi.nlm.nih.gov/pubmed/16735576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200510155 |
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