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Use of Divalent Metal Ions in the DNA Cleavage Reaction of Human Type II Topoisomerases
All type II topoisomerases require divalent metal ions in order to cleave and ligate DNA. In order to further elucidate the mechanistic basis for these critical enzyme-mediated events, the role of the metal ion in the DNA cleavage reaction of human topoisomerase IIβ was characterized and compared to...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693261/ https://ncbi.nlm.nih.gov/pubmed/19222228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8023256 |
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