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Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase ι
Human DNA polymerase ι (polι) is a unique member of Y-family polymerases, which preferentially misincorporates nucleotides opposite thymines (T) and halts replication at T bases. The structural basis of the high error rates remains elusive. We present three crystal structures of polι complexed with...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693154/ https://ncbi.nlm.nih.gov/pubmed/19440206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.122 |
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