Structural basis of error-prone DNA synthesis by DNA polymerase θ
Abstract DNA polymerase θ (Pol θ) is an A-family DNA polymerase specialized in DNA double-strand breaks repair and translesion synthesis. Distinct from its high-fidelity homologs in DNA replication, Pol θ catalyzes template-dependent DNA synthesis with an inherent propensity for error incorporation....
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Nature Portfolio
2025-02-01
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| Schriftenreihe: | Nature Communications |
| Online-Zugang: | https://doi.org/10.1038/s41467-025-57269-9 |
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