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Structural Mechanism of Replication Stalling on a Bulky Amino-Polycyclic Aromatic Hydrocarbon DNA Adduct by a Y Family DNA Polymerase

Polycyclic aromatic hydrocarbons and their nitro derivatives are culprits of the detrimental health effects of environmental pollution. These hydrophobic compounds metabolize to reactive species and attach to DNA producing bulky lesions, such as N-[deoxyguanosine-8-yl]-1-aminopyrene (APG), in genomi...

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Detalhes bibliográficos
Main Authors: Kirouac, Kevin N., Basu, Ashis K., Ling, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894629/
https://ncbi.nlm.nih.gov/pubmed/23876706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.07.020
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