Mechanistic Investigation of the Bypass of a Bulky Aromatic DNA Adduct Catalyzed by a Y-family DNA Polymerase

3-Nitrobenzanthrone (3-NBA), a nitropolyaromatic hydrocarbon (NitroPAH) pollutant in diesel exhaust, is a potent mutagen and carcinogen. After metabolic activation, the primary metabolites of 3-NBA react with DNA to form dG and dA adducts. One of the three major adducts identified is N-(2’-deoxyguan...

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Hlavní autoři: Gadkari, Varun V., Tokarsky, E. John, Malik, Chanchal K., Basu, Ashis K., Suo, Zucai
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133103/
https://ncbi.nlm.nih.gov/pubmed/25048879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.06.003
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