Kinetic Analysis of the Bypass of a Bulky DNA Lesion Catalyzed by Human Y-family DNA Polymerases

1-Nitropyrene (1-NP), a mutagen and potential carcinogen, is the most abundant nitro polyaromatic hydrocarbon in diesel exhaust, which reacts with DNA to form predominantly N-(deoxyguanosin-8-yl)-1-aminopyrene (dG(AP)). If not repaired, this DNA lesion is presumably bypassed in vivo by any of human...

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Detalhes bibliográficos
Principais autores: Sherrer, Shanen M., Sanman, Laura E., Xia, Cynthia X., Bolin, Eric R., Malik, Chanchal K., Efthimiopoulos, Georgia, Basu, Ashis K., Suo, Zucai
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307895/
https://ncbi.nlm.nih.gov/pubmed/22324639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200531y
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