Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase

1-Nitropyrene (1-NP), an environmental pollutant, induces DNA damage in vivo and is considered to be carcinogenic. The DNA adducts formed by the 1-NP metabolites stall replicative DNA polymerases but are presumably bypassed by error-prone Y-family DNA polymerases at the expense of replication fideli...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Vyas, Rajan, Efthimiopoulos, Georgia, Tokarsky, E. John, Malik, Chanchal K., Basu, Ashis K., Suo, Zucai
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582013/
https://ncbi.nlm.nih.gov/pubmed/26327169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b08027
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