Mechanistic Studies of the Bypass of a Bulky Single-base Lesion Catalyzed by a Y-family DNA Polymerase

1-Nitropyrene, the most abundant nitro polycyclic aromatic hydrocarbon in diesel emissions, has been found to react with DNA to form predominantly N-(deoxyguanosin-8-yl)-1-aminopyrene (dG(AP)). This bulky adduct has been shown to induce genetic mutations, which may implicate Y-family DNA polymerases...

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Main Authors: Sherrer, Shanen M., Brown, Jessica A., Pack, Lindsey R., Jasti, Vijay P., Fowler, Jason D., Basu, Ashis K., Suo, Zucai
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649090/
https://ncbi.nlm.nih.gov/pubmed/19124465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808161200
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