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Preparation of Site-specific T=(m)CG cis-syn Cyclobutane Dimer-containing Template and Its Error-free Bypass by Yeast and Human Polymerase η
C-to-T mutations are a hallmark of UV light and, in humans, occur preferentially at methylated Py(m)CG sites, which are also sites of preferential cyclobutane pyrimidine dimer (CPD) formation. In response, cells have evolved DNA damage bypass polymerases, of which polymerase η (pol η) appears to be...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318691/ https://ncbi.nlm.nih.gov/pubmed/22262850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333591 |
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