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Chemical synthesis and translesion replication of a cis–syn cyclobutane thymine–uracil dimer
The cytosine base in DNA undergoes hydrolytic deamination at a considerable rate when UV radiation induces formation of a cyclobutane pyrimidine dimer (CPD) with an adjacent pyrimidine base. We have synthesized a phosphoramidite building block of a cis–syn cyclobutane thymine–uracil dimer (T[]U), wh...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC390339/ https://ncbi.nlm.nih.gov/pubmed/15020710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh342 |
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