Fragment-Based Design of Small Molecule X-Linked Inhibitor of Apoptosis Protein Inhibitors

We report on a general structure- and NMR- based approach to derive drug-like small molecule inhibitors of protein-protein interactions in a rapid and efficient manner. We demonstrate the utility of the approach by deriving novel and effective SMAC mimetics targeting the anti-apoptotic protein X-Lin...

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Hauptverfasser: Huang, Jui-Wen, Zhang, Ziming, Wu, Bainan, Cellitti, Jason F., Zhang, Xiyun, Dahl, Russell, Shiau, Chung-Wai, Welsh, Kate, Emdadi, Aras, Stebbins, John L., Reed, John C., Pellecchia, Maurizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692895/
https://ncbi.nlm.nih.gov/pubmed/18956862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8006992
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