Gamma-secretase inhibitors reverse glucocorticoid resistance in T-ALL

Gamma-secretase inhibitors (GSIs) block the activation of oncogenic NOTCH1 in T-cell acute lymphoblastic leukemia (T-ALL). However, limited antileukemic cytotoxicity and severe gastrointestinal toxicity have restricted the clinical application of these targeted drugs. Here we show that combination t...

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Autori principali: Real, Pedro J., Tosello, Valeria, Palomero, Teresa, Castillo, Mireia, Hernando, Eva, de Stanchina, Elisa, Sulis, Maria Luisa, Barnes, Kelly, Sawai, Catherine, Homminga, Irene, Meijerink, Jules, Aifantis, Iannis, Basso, Giuseppe, Cordon-Cardo, Carlos, Ai, Walden, Ferrando, Adolfo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692090/
https://ncbi.nlm.nih.gov/pubmed/19098907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1900
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