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NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia
Inhibition of NOTCH1 signaling with gamma-secretase inhibitors (GSIs), has been proposed a molecularly targeted therapy in T-cell acute lymphoblastic leukemia (T-ALL). However, GSIs seem to have limited antileukemic activity in human T-ALL and are associated with severe gastrointestinal toxicity res...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2814171/ https://ncbi.nlm.nih.gov/pubmed/19357700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2009.75 |
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