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The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is characterized by aberrant activation of NOTCH1 in over 60% of T-ALL cases. The high prevalence of activating NOTCH1 mutations highlights the critical role of NOTCH signaling in the pathogenesis of this disease and has prompted the development o...

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Autors principals: Tosello, Valeria, Ferrando, Adolfo A.
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666445/
https://ncbi.nlm.nih.gov/pubmed/23730497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040620712471368
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