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The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy
T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is characterized by aberrant activation of NOTCH1 in over 60% of T-ALL cases. The high prevalence of activating NOTCH1 mutations highlights the critical role of NOTCH signaling in the pathogenesis of this disease and has prompted the development o...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3666445/ https://ncbi.nlm.nih.gov/pubmed/23730497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040620712471368 |
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