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Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins

A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by diso...

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Bibliographic Details
Main Authors: Chan, Hue Sun, Zhang, Zhuqing
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689430/
https://ncbi.nlm.nih.gov/pubmed/19344476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/jbiol126
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