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Native Topology of the Designed Protein Top7 is Not Conducive to Cooperative Folding

Many single-domain proteins with <100 residues fold cooperatively; but the recently designed 92-residue Top7 protein exhibits clearly non-two-state behaviors. In apparent agreement with experiment, we found that coarse-grained, native-centric chain models, including potentials with and without el...

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Hlavní autoři: Zhang, Zhuqing, Chan, Hue Sun
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716685/
https://ncbi.nlm.nih.gov/pubmed/19186118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.11.004
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