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Competition between native topology and nonnative interactions in simple and complex folding kinetics of natural and designed proteins

We compared folding properties of designed protein Top7 and natural protein S6 by using coarse-grained chain models with a mainly native-centric construct that accounted also for nonnative hydrophobic interactions and desolvation barriers. Top7 and S6 have similar secondary structure elements and ar...

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Bibliografske podrobnosti
Main Authors: Zhang, Zhuqing, Chan, Hue Sun
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840274/
https://ncbi.nlm.nih.gov/pubmed/20133730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911844107
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