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Native Topology of the Designed Protein Top7 is Not Conducive to Cooperative Folding
Many single-domain proteins with <100 residues fold cooperatively; but the recently designed 92-residue Top7 protein exhibits clearly non-two-state behaviors. In apparent agreement with experiment, we found that coarse-grained, native-centric chain models, including potentials with and without el...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2716685/ https://ncbi.nlm.nih.gov/pubmed/19186118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.11.004 |
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