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Release of long-range tertiary interactions potentiates aggregation of natively unstructured α-synuclein
In idiopathic Parkinson's disease, intracytoplasmic neuronal inclusions (Lewy bodies) containing aggregates of the protein α-synuclein (αS) are deposited in the pigmented nuclei of the brainstem. The mechanisms underlying the structural transition of innocuous, presumably natively unfolded, αS...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2005
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC547830/ https://ncbi.nlm.nih.gov/pubmed/15671169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407146102 |
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