Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other neurodegenerative synucleinopathies. We demonstrate here that Cu(II) ions are effective in accelerating AS aggregation at physiologically relevant concentrations without altering the resultant fibrillar struc...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Rasia, Rodolfo M., Bertoncini, Carlos W., Marsh, Derek, Hoyer, Wolfgang, Cherny, Dmitry, Zweckstetter, Markus, Griesinger, Christian, Jovin, Thomas M., Fernández, Claudio O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC555498/
https://ncbi.nlm.nih.gov/pubmed/15767574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407881102
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados